Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

492
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
492
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.3K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

430
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
430
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

402
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
402
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Physiology and immunology of a pig-to-human decedent kidney xenotransplant.

Nature·2026
Same author

Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy.

The New England journal of medicine·2026
Same author

Bridging monitoring gaps in global drylands with big data and collaboration.

npj biodiversity·2026
Same author

Contemporary Trends in Heart Failure Mortality: The Pandemic Ended, the Epidemic Continues.

JACC. Heart failure·2026
Same author

Cardiac-Gated Diffusion-Weighted Magnetic Resonance Imaging Assessment of Kidney Function in Patients With Kidney Cancer.

Kidney international reports·2026
Same author

Hypothermic vs Normothermic Machine Perfusion in Liver Transplantation in the US: A Cohort Study.

Journal of the American College of Surgeons·2026
Same journal

Beyond consent: community engagement, benefit sharing and reciprocity in kidney genomics research.

Nature reviews. Nephrology·2026
Same journal

The social needs of patients with kidney failure.

Nature reviews. Nephrology·2026
Same journal

Long-term kidney protection in IgA nephropathy with atrasentan.

Nature reviews. Nephrology·2026
Same journal

Benefits of finerenone treatment across chronic kidney disease aetiologies.

Nature reviews. Nephrology·2026
Same journal

The versatile roles of long non-coding RNAs in kidney disease.

Nature reviews. Nephrology·2026
Same journal

Sequential therapeutic approach for the management of osteoporosis in people with chronic kidney disease.

Nature reviews. Nephrology·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.6K

HLA in transplantation.

Robert A Montgomery1, Vasishta S Tatapudi2, Mary S Leffell3

  • 1NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. robert.montgomery@nyumc.org.

Nature Reviews. Nephrology
|July 10, 2018
PubMed
Summary
This summary is machine-generated.

Advances in human leukocyte antigen (HLA) technology improve organ transplantation safety and access for sensitized patients. New methods enhance desensitization, immunomodulation, and tolerance induction, making transplantation more achievable.

More Related Videos

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.9K
Optimization of the Cuff Technique for Murine Heart Transplantation
14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

10.1K

Related Experiment Videos

Last Updated: Feb 8, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.6K
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.9K
Optimization of the Cuff Technique for Murine Heart Transplantation
14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

10.1K

Area of Science:

  • Immunogenetics
  • Transplantation Immunology

Background:

  • The human major histocompatibility complex (MHC) encodes human leukocyte antigens (HLAs), critical for immune responses against pathogens and tumors.
  • In transplantation, HLAs act as polymorphic antigens triggering immune responses and potential rejection.
  • Sensitization to HLAs significantly reduces transplantation access for many patients.

Purpose of the Study:

  • To review advancements in HLA understanding and technology.
  • To highlight how these advancements improve organ transplantation safety and accessibility.
  • To discuss novel strategies for overcoming HLA barriers in transplantation.

Main Methods:

  • Review of immunogenetic knowledge and technological progress in HLA detection and tracking.
  • Analysis of new approaches in plasmapheresis, intravenous immunoglobulin, and kidney paired donation.
  • Examination of novel protocols for tolerance induction and immunomodulation.

Main Results:

  • Significant enhancements in transplantation safety due to immunogenetic advances.
  • Improved detection and tracking of anti-HLA antibodies facilitate crossing the HLA barrier.
  • New desensitization and immunomodulation strategies are emerging.

Conclusions:

  • Progress in HLA understanding has made organ transplantation more accessible, even for sensitized individuals.
  • Novel desensitization, immunomodulation, and tolerance induction approaches hold potential for further improving transplant access and outcomes.
  • Continued research in HLA technology is vital for advancing transplantation medicine.