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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Periorbital desmoplastic squamous cell carcinoma.
Verona E Botha1, Kent T K Chow1, Paul J M Salmon2
1a Department of Ophthalmology , Waikato Hospital , Hamilton , New Zealand.
Orbit (Amsterdam, Netherlands)
|July 10, 2018
Summary
Desmoplastic squamous cell carcinoma (SCC) is a rare but aggressive cancer. In the periorbital region, it poses a significant risk of local recurrence and can be sight- and life-threatening.
Area of Science:
- Oncology
- Dermatology
- Ophthalmology
Background:
- Desmoplasia, the formation of a dense collagenous stroma around a neoplasm, is associated with various malignancies.
- Cutaneous squamous cell carcinoma (SCC) can exhibit desmoplasia, which is an independent risk factor for recurrence and metastasis.
- The periorbital region presents unique challenges for managing aggressive skin cancers due to proximity to vital structures.
Observation:
- A case series identified seven patients with desmoplastic SCC in the periorbital region.
- The median age of affected patients was 68 years, with a male predominance (4 out of 7).
- Mean follow-up was 48 months.
Findings:
- 29% of patients (2 out of 7) experienced aggressive local recurrence.
- One patient required extensive salvage surgery, including orbital exenteration, parotidectomy, and neck dissection.
- Another patient needed repeat excision and adjuvant radiotherapy for recurrent disease.
Implications:
- Desmoplastic SCC is an uncommon but highly aggressive subtype of cutaneous malignancy.
- In the periorbital area, this subtype carries a high risk of orbital invasion.
- Early recognition and aggressive management are crucial due to the potential sight- and life-threatening nature of periorbital desmoplastic SCC.
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