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Curative cancer chemotherapy.

E Frei

    Cancer Research
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Cancer chemotherapy offers curative treatment for some cancers through combination chemotherapy and adjuvant therapy. Advances in molecular biology promise more effective future cancer treatments.

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    Area of Science:

    • Oncology
    • Pharmacology
    • Clinical Trials

    Background:

    • Cancer chemotherapy has evolved significantly, offering effective treatment for many human cancers and curative options for specific types.
    • Progress stems from integrated scientific efforts including drug development, preclinical modeling, and clinical trial design.

    Purpose of the Study:

    • To review the principles and advancements in cancer chemotherapy that have led to curative treatments.
    • To highlight the role of combination chemotherapy, adjuvant chemotherapy, and emerging strategies.

    Main Methods:

    • Review of clinical trials, focusing on complete remission, dose, schedule, sequencing, and combination chemotherapy.
    • Analysis of adjuvant chemotherapy's effectiveness in high-risk patients with microscopic disease.

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  • Examination of principles derived from studies, particularly in pediatric acute lymphocytic leukemia.

    • Main Results:

    • Combination chemotherapy has achieved curative treatment for disseminated Hodgkin's disease, non-Hodgkin's lymphoma, pediatric solid tumors, testicular cancer, and limited small cell lung cancer.
    • Adjuvant chemotherapy has successfully increased cure rates in pediatric solid tumors and prolonged disease-free survival in premenopausal breast cancer.
    • An estimated 15,000-30,000 patients annually in the US are potentially curable with current chemotherapy.

    Conclusions:

    • Cancer chemotherapy, particularly combination and adjuvant approaches, has led to significant improvements in cancer curability.
    • Chemotherapy's curability is generally inversely related to age, with most curable tumors occurring in children and young adults.
    • Advances in molecular and cellular biology are paving the way for novel and more effective chemotherapeutic strategies.