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Multiplexed Biomolecular Arrays Generated via Parallel Dip-Pen Nanolithography
Hui Ma1, Zhang Jiang1, Xiaoji Xie1
1Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM) , Nanjing Tech University , 30 South Puzhu Road , Nanjing 211816 , China.
ACS Applied Materials & Interfaces
|July 10, 2018
Summary
This study introduces parallel dip-pen nanolithography for simultaneous biomolecule patterning. This technique enables precise, multiplexed biofunctional arrays for applications in disease diagnosis and drug screening.
Area of Science:
- Biotechnology
- Nanoscience
- Materials Science
Background:
- Precise patterning of biomolecules is crucial for advanced diagnostics and screening.
- Existing methods face challenges in multiplexing and controlling feature size.
Purpose of the Study:
- To develop a method for simultaneous patterning of multiple biomolecules.
- To enable high-throughput disease diagnosis, multiplexing, and drug screening.
Main Methods:
- Utilized parallel dip-pen nanolithography with an array of atomic force microscope (AFM) tips.
- Developed a novel inkwell array for selective and alternating biomolecule coating.
- Incorporated polyethylene glycol in a PBS buffer solution as an ink carrier.
Main Results:
- Successfully achieved simultaneous patterning of two types of biomolecules.
- Demonstrated reliable generation of multiplexed biofunctional dot and/or line arrays with similar sizes.
- Showcased controlled ink diffusion for consistent feature generation.
Conclusions:
- Parallel dip-pen nanolithography offers a robust platform for multiplexed biomolecule patterning.
- The developed method enhances capabilities for high-throughput biological assays and diagnostics.
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