Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.3K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
Nucleosome Remodeling02:54

Nucleosome Remodeling

11.2K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.2K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

6.0K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
6.0K
Convergent Evolution01:54

Convergent Evolution

33.0K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.0K
Centrosome Duplication02:25

Centrosome Duplication

5.0K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
5.0K
Eukaryotic Evolution01:24

Eukaryotic Evolution

42.1K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
42.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.

EMBO reports·2026
Same author

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation.

Cytoskeleton (Hoboken, N.J.)·2025
Same author

Cell biology meets climate resilience - a call to action.

Journal of cell science·2025
Same author

Centrosome biogenesis and maintenance in homeostasis and disease.

Current opinion in cell biology·2025
Same author

EU-LIFE charter of independent life science research institutes.

FEBS letters·2024
Same author

IFT88 maintains sensory function by localising signalling proteins along <i>Drosophila</i> cilia.

Life science alliance·2024

Related Experiment Video

Updated: Feb 8, 2026

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.5K

Centrosome Remodelling in Evolution.

Daisuke Ito1, Mónica Bettencourt-Dias2

  • 1Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. dito@igc.gulbenkian.pt.

Cells
|July 11, 2018
PubMed
Summary

Yeast spindle pole bodies (SPBs) evolved from ancestral centrosomes lacking centrioles. These acentriolar structures retained pericentriolar matrix components essential for microtubule nucleation, suggesting a stepwise assembly process.

Keywords:
PCMSPBcentriolecentrosomeevolutionspindle pole body

More Related Videos

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

15.8K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K

Related Experiment Videos

Last Updated: Feb 8, 2026

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.5K
Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

15.8K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K

Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Microtubule Dynamics

Background:

  • Centrosomes, the primary microtubule organizing centers (MTOCs) in animal cells, typically consist of centrioles within a pericentriolar matrix (PCM).
  • Yeasts and amoebozoa possess acentriolar centrosomes, termed spindle pole bodies (SPBs) and nucleus-associated bodies (NABs), respectively, which lack centrioles.
  • Despite structural differences, centriolar centrosomes and SPBs share molecular components and biogenesis regulators.

Purpose of the Study:

  • To review the structure and evolution of the yeast spindle pole body (SPB).
  • To speculate on the evolutionary pathway of acentriolar centrosomes from ancestral centriolar centrosomes.
  • To highlight the importance of acentriolar centrosomes in understanding centrosome evolution and biogenesis.

Main Methods:

  • Phylogenetic analysis of molecular components.
  • Comparative structural analysis of centrosomes and SPBs.
  • Review of existing literature on centrosome and SPB biogenesis.

Main Results:

  • Phylogenetic data indicate yeasts acquired unique SPB components after losing centrioles but retained PCM components.
  • The pericentriolar matrix (PCM) likely persisted post-centrosome evolution due to its essential role in microtubule nucleation.
  • A step-wise model for yeast SPB formation is proposed: precursor appearance, interaction with PCM and nuclear envelope, and replacement of centriole function.

Conclusions:

  • The yeast SPB evolved through a gradual process, adapting from an ancestral centriolar centrosome.
  • Acentriolar centrosomes, like the yeast SPB, provide valuable insights into the fundamental mechanisms of centrosome evolution and regulation.
  • Understanding acentriolar centrosomes is crucial for deciphering the diverse strategies of microtubule organization across eukaryotes.