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Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care
R Chingono1, H Mebrahtu2, Z Mupambireyi1,3
1Centre for Sexual Health HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
Insights
This study tested a combined early childhood stimulation and savings program for HIV-exposed infants in Zimbabwe. The intervention aimed to improve child development and retention in HIV care.
Area of Science:
- Global Health
- Developmental Pediatrics
- Public Health Interventions
Background:
- Family HIV infection can impede optimal child development.
- Early childhood stimulation (ECS) and financial programs may improve outcomes for HIV-exposed infants.
Purpose of the Study:
- To evaluate the impact of a multi-component intervention on cognitive development and retention in care for HIV-exposed infants.
- To assess the effectiveness of an early childhood stimulation program combined with a savings and loans scheme for parents.
Main Methods:
- Cluster-randomized controlled trial in 30 clinics in Zimbabwe.
- Intervention group received the Child Health Intervention for Development Outcomes (CHIDO) program (ECS, savings/loans, home visits).
- Control group received standard care; primary outcomes were cognitive development and retention in HIV care at 12 months.
Main Results:
- The study results are anticipated to offer crucial insights into interventions for developmental delays in HIV-exposed infants.
- The findings will be significant for resource-limited settings.
Conclusions:
- Multi-component interventions show promise in mitigating developmental delays in HIV-exposed infants.
- The CHIDO intervention could be a valuable model for improving child development outcomes in vulnerable populations.
Background:
HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.
Methods:
The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted.
Discussion:
The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.
Trial Registration:
This trial is registered with the Pan African Clinical Trials Registry ( www.pactr.org ), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered).
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