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Aerobic exercise-based cardiac rehabilitation in Chinese patients with coronary heart disease: study protocol for a

Richard Y Cao1, Hongchao Zheng2, Qiongyao Mi2

  • 1The Joint Laboratory of Cardiac Rehabilitation, Shanghai Xuhui Central Hospital & Shanghai University, 966 Middle Huaihai Road, 200031 & 99 Shangda Road, Shanghai, 200444, China. rycao@scrc.ac.cn.

Trials
|July 11, 2018
PubMed

Insights

This pilot study explores aerobic exercise-based cardiac rehabilitation (CR) for Chinese patients with coronary heart disease (CHD). It assesses CR feasibility, aerobic capacity, and molecular biomarkers to improve cardiovascular health.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Biochemistry

Background:

  • Cardiovascular disease (CVD) is a major global health burden, particularly in China.
  • Cardiac rehabilitation (CR) effectively reduces cardiovascular mortality and adverse events.
  • Aerobic exercise-based CR shows promise for managing coronary heart disease (CHD).

Purpose of the Study:

  • To evaluate the feasibility of an 8-week aerobic exercise-based CR program in Chinese patients with CHD.
  • To assess the impact of targeted aerobic exercise on aerobic metabolism capacity.
  • To explore changes in molecular biomarkers related to cardiovascular function.

Main Methods:

  • Pilot, single-center, randomized controlled trial in Shanghai.
  • Forty patients with CHD post-percutaneous coronary intervention were randomized.
  • Intervention group: 8 weeks of targeted aerobic exercise; Control group: 8 weeks of leisure exercise.

Main Results:

  • Feasibility of the CR trial was the primary outcome.
  • Secondary outcomes included changes in aerobic metabolism capacity.
  • Exploratory outcomes involved screening molecular biomarkers for cardiovascular function.

Conclusions:

  • This is the first prospective randomized controlled study in China on aerobic exercise for CHD patients.
  • It comprehensively screens blood biomarkers to elucidate molecular mechanisms of aerobic exercise benefits.
  • Findings will inform future CR study designs for CHD patients in China.
Abstract

Keywords:
Aerobic metabolismBiomarkerCardiac rehabilitationCoronary heart diseaseProtocolRandomization

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