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Effect of Cumulative Intravenous Voriconazole Dose on Renal Function in Hematological Patients
Takeo Yasu1, Takaaki Konuma2, Seiichiro Kuroda1
1Department of Pharmacy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Abstract:
Intravenous voriconazole (VRC) is formulated by the incorporation of sulfobutylether-β-cyclodextrin (SBECD), which may accumulate to adversely affect renal function. However, the effect of long-term use of intravenous VRC on renal function is unclear. Our retrospective analysis of data confirmed that worsening of renal function was significantly associated with a cumulative dose of intravenous VRC (≥400 mg/kg), suggesting that a higher cumulative dose of intravenous VRC is a risk factor for renal dysfunction.
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