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09:11
Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
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Pollen-Structured Gold Nanoclusters for X-ray Induced Photodynamic Therapy
Lih Shin Tew1,2, Meng-Ting Cai3, Leu-Wei Lo4
1Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas 13200, Malaysia. tls16_ipg005@student.usm.my.
Materials (Basel, Switzerland)
|July 11, 2018
Summary
Pollen-structured gold clusters enhance X-ray-induced photodynamic therapy (PDT) for deep-tissue cancer treatment. These clusters effectively generate reactive oxygen species (ROS) to induce cancer cell death, improving radiotherapy outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Photodynamic therapy (PDT) is limited by light penetration depth for treating deep-seated tumors.
- Conventional PDT relies on light activation, restricting its application in deeper tissues.
- There is a need for innovative approaches to enhance PDT efficacy in challenging cancer sites.
Purpose of the Study:
- To design and synthesize pollen-structured gold clusters (PSGCs) for X-ray-induced PDT.
- To evaluate the reactive oxygen species (ROS) generation capacity of PSGCs under X-ray irradiation.
- To assess the efficacy of PSGC-mediated PDT in breast cancer cells for potential radiotherapy enhancement.
Main Methods:
- Synthesis of pollen-structured gold clusters (PSGCs).
- X-ray irradiation of PSGCs followed by quantification of generated ROS using dihydroethidium (DHE) assay.
- Evaluation of cellular PDT efficacy through immunofluorescence staining for γ-H2AX and comet assay in breast cancer cells.
Main Results:
- PSGCs demonstrated a significant capacity for ROS generation upon X-ray irradiation.
- PSGCs exhibited remarkable PDT efficacy in treating breast cancer cells.
- The study confirmed the potential of PSGCs in enhancing radiotherapy for deep-tissue cancers.
Conclusions:
- PSGCs are effective agents for X-ray-induced PDT, overcoming light penetration limitations.
- The high ROS-generating ability and cellular efficacy of PSGCs show promise for clinical applications in deep-tissue cancer treatment.
- PSGCs represent a viable strategy for improving radiotherapy outcomes in oncology.
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