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Limbic encephalitis as a relapse of Whipple's disease with digestive involvement and spondylodiscitis
Didier Brönnimann1, Marc-Olivier Vareil2, Igor Sibon3,4
1Service de médecine interne et pathologies infectieuses, CHU de Bordeaux, Groupe Hospitalier Saint André, hôpital Saint André, 1 rue Jean Burguet, 33000, Bordeaux Cedex, France. didier.bronnimann@chu-bordeaux.fr.
Infection
|July 11, 2018
Abstract
Introduction:
Many clinical manifestations can be related to Tropheryma whipplei infection.
Case Report:
We report a Tropheryma whipplei limbic encephalitis developed as a relapse of classical Whipple's disease.
Discussion:
This case is to the best of our knowledge the first proof of the effective brain-blood barrier crossing of both doxycycline and hydroxychloroquine as demonstrated by direct concentration monitoring on brain biopsy.