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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Risk factors for inflammatory bowel disease: A prospective multi-center study.

Anjali D Amarapurkar1, Deepak N Amarapurkar2, Pravin Rathi3

  • 1Department of Pathology, Topiwala National Medical College and B Y L Nair Charitable Hospital, Mumbai, 400 008, India. anjali1963@gmail.com.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|July 11, 2018
PubMed
Summary
This summary is machine-generated.

Environmental factors and lifestyle choices significantly influence inflammatory bowel disease (IBD) risk. Higher education, income, and appendectomy history are linked to increased IBD, while vegetarian diets may be protective for ulcerative colitis.

Keywords:
Crohn’s diseaseExtraintestinal manifestationsUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Epidemiology
  • Public Health

Background:

  • Environmental factors are increasingly recognized as contributors to inflammatory bowel disease (IBD) incidence.
  • Understanding population-specific risk factors is crucial given the rising global prevalence of IBD.
  • This study investigates environmental and lifestyle-related risk factors for IBD in western India.

Purpose of the Study:

  • To identify and evaluate key risk factors associated with inflammatory bowel disease (IBD) in a western Indian population.
  • To differentiate risk factors for ulcerative colitis (UC) and Crohn's disease (CD) within the study cohort.

Main Methods:

  • A prospective, multi-center case-control study involving 1054 IBD patients (765 UC, 289 CD) and asymptomatic controls.
  • Data on potential risk factors were collected using questionnaires administered to both patient and control groups.
  • Statistical analysis included calculating odds ratios (OR) and 95% confidence intervals (CI) for each variable.

Main Results:

  • Higher education, professional occupation, and annual family income exceeding 100,000 Indian rupees were significant risk factors for both UC and CD.
  • A history of appendectomy and a family history of IBD were strongly associated with increased risk for both conditions.
  • While a vegetarian diet showed a protective effect for UC (OR 0.29), it was a potential risk factor for CD (OR 1.179). Rural environment was a risk factor for CD.
  • Smoking and chronic alcoholism were not identified as significant risk factors in this population.

Conclusions:

  • Socioeconomic status, dietary patterns, appendectomy history, and family history are significant determinants of IBD risk in western India.
  • These findings underscore the complex interplay between environmental, genetic, and lifestyle factors in the etiology of IBD.
  • Further research can inform targeted prevention and management strategies for IBD based on identified risk factors.