Related Experiment Video
Updated: Feb 8, 2026

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
Published on: March 4, 2016
The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery
Toshihiko Isaji1,2,3, Alan Dardik4,5,6
1Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.
Abstract:
The arteriovenous fistula (AVF) is the most common type of vascular access currently used for hemodialysis, but long-term outcomes remain poor in many patients; understanding the basic mechanisms of venous remodeling within the fistula environment is critical to improve our understanding of AVF maturation. In this chapter, we describe a method to create a murine aortocaval fistula that allows intraluminal drug delivery. This model reliably recapitulates human AVF maturation and therefore is a good consideration to study venous remodeling.
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