Inflammation and immune resolution

Area of Science:

• Immunology
• Inflammation research

Background:

• This review series, inspired by the 2017 British Society for Immunology Congress, focuses on inflammation and immune resolution.
• It covers genetic similarities and differences in immune-mediated inflammatory diseases (IMIDs).

Discussion:

• Explores aberrant myeloid cell activation in rheumatoid arthritis (RA) and their role in immune resolution.
• Discusses innate immune memory in stromal cells and its impact on inflammatory diseases.
• Reviews the roles of interleukin (IL)-6 and IL-27 in driving or regulating inflammation.

Key Insights:

• Understanding the genetic basis of IMIDs is crucial.
• Myeloid cells and innate immune memory significantly influence inflammatory processes.
• Cytokines like IL-6 and IL-27 are key regulators of inflammation and resolution.

Outlook:

• Further research into the balance between inflammation and immune resolution is needed.
• This series provides insights into complex immune mechanisms for better disease management.