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The distribution of BCG prostatitis: A clue for pathogenetic processes?
1Department of Histopathology, Norfolk and Waveney Cellular Pathology Service, The Cotman Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK.
The Prostate
|July 11, 2018
Summary
Bacillus Calmette-Guérin (BCG) prostatitis preferentially affects the prostate
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- Bacillus Calmette-Guérin (BCG) granulomatous prostatitis observed in cystoprostatectomy specimens.
- Preferential involvement of the peripheral zone (PZ) noted.
- Study aimed to understand pathogenetic processes of BCG prostatitis distribution.
Purpose of the Study:
- Determine the anatomical distribution and histopathological characteristics of BCG prostatitis.
- Investigate the role of prostatic duct microanatomy in BCG prostatitis pathogenesis.
- Explore potential implications for other prostatic diseases.
Main Methods:
- Whole-mount sections of entire prostate glands from 27 men studied.
- Patients had prior intravesical BCG therapy for urothelial carcinoma.
- Anatomical distribution and histopathological features of BCG prostatitis assessed.
Main Results:
- BCG-type granulomatous inflammation found in 81.5% of prostates.
- Predominantly or exclusively peripheral zone (PZ) involvement in 95.5% of cases.
- No granulomas observed in the central zone or anterior fibromuscular septum.
Conclusions:
- Prostatic duct microanatomy is a key factor in BCG prostatitis pathogenesis.
- PZ ducts' entry angle into the urethra may increase susceptibility to BCG.
- Prostatic duct microanatomy may influence pathogenesis of other prostatic diseases, including adenocarcinoma.
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