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PATIENT PRIORITIES FOR TREATMENT ATTRIBUTES IN ADJUNCTIVE DRUG THERAPY OF SEVERE HYPERCHOLESTEROLEMIA IN GERMANY: AN

Axel C Mühlbacher1, Anika Kaczynski2, Franz-Werner Dippel3

  • 1Hochschule Neubrandenburg;Gesellschaft für empirische Beratung GmbH (GEB)muehlbacher@hs-nb.de.

International Journal of Technology Assessment in Health Care
|July 11, 2018
PubMed
Abstract

Insights

Patients with severe hypercholesterolemia prioritize LDL-C reduction above other factors in adjunctive apheresis therapy. Side effects and frequency of treatment are also key considerations.

Area of Science:

  • Cardiology
  • Pharmacoeconomics
  • Patient-centered care

Background:

  • Severe hypercholesterolemia significantly contributes to coronary heart disease mortality.
  • Recent advancements include new adjunctive drug therapies for hypercholesterolemia management.
  • Patient preferences for these new therapies remain largely uncharacterized.

Purpose of the Study:

  • To identify and evaluate patient priorities for adjunctive drug therapies in hypercholesterolemia, specifically in the context of apheresis.
  • To determine the relative importance of various therapy characteristics from the patient's perspective.

Main Methods:

  • A systematic literature review and ten patient interviews were conducted to identify relevant treatment characteristics.
  • An analytic hierarchy process (AHP) was employed to elicit and quantify patient priorities among seven key characteristics.
  • Sixty-one patients with severe hypercholesterolemia undergoing apheresis participated.

Main Results:

  • The most significant patient-valued attribute was "reduction of LDL-C level in blood" (Wglobal:0.362).
  • "Risk of myopathy" (Wglobal:0.164), "risk of neurocognitive impairment" (Wglobal:0.161), and "frequency of apheresis" (Wglobal:0.119) were the next highest-ranked characteristics.
  • Younger patients, men, and those reporting reduced quality of life due to apheresis placed greater importance on the "frequency of apheresis".

Conclusions:

  • Patient priorities for adjunctive hypercholesterolemia therapy center on lipoprotein reduction, administration mode, and side effect profiles.
  • This study provides a transparent methodology for understanding patient-centered endpoints in adjunctive PCSK9-inhibitor therapy for apheresis-treated hypercholesterolemia.
  • Findings can guide healthcare decision-makers in optimizing treatment strategies based on patient values.
Keywords:
Adjunctive drug therapyAnalytic Hierarchy Process (AHP)Lipoprotein apheresisPatient prioritiesSevere hypercholesterolemia

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