Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in

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Updated: Feb 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.9K

Heini M L Kallio1, Reija Hieta2, Leena Latonen2

  • 1Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, Finland. heini.kallio@uta.fi.

British Journal of Cancer
|July 11, 2018
PubMed
Abstract

Insights

Castration-resistant prostate cancer (CRPC) often resists treatment due to androgen receptor splice variants (AR-Vs). This study found AR-V3, AR-V7, and AR-V9 are co-expressed in CRPC, suggesting therapies targeting common AR regions could benefit patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PC) patients with castration-resistant prostate cancer (CRPC) often exhibit primary resistance to androgen receptor (AR)-targeting drugs.
  • Constitutively active AR splice variants (AR-Vs) are a potential explanation for this drug resistance.
  • Understanding AR aberrations is crucial for developing effective CRPC treatments.

Purpose of the Study:

  • To investigate the expression of AR splice variants (AR-Vs) and other AR aberrations in CRPC.
  • To elucidate the role of AR aberrations in the emergence of castration-resistant prostate cancer.
  • To identify potential therapeutic targets for CRPC.

Main Methods:

  • Analysis of prostate cancer specimens across different disease stages.
  • Utilized next-generation sequencing and immunohistochemistry techniques.
  • Detected AR mutations, copy number variations, and genomic structural rearrangements.

Main Results:

  • AR mutations and copy number variations were exclusively found in CRPC specimens.
  • Genomic structural rearrangements of AR were observed in 5/30 metastatic CRPC patients.
  • Predominant AR-Vs (AR-V3, AR-V7, AR-V9) were significantly overexpressed in CRPC compared to prostatectomy samples, with frequent co-expression.

Conclusions:

  • AR-V3, AR-V7, and AR-V9 are co-expressed in CRPC metastases.
  • Targeting AR regions common to all AR-Vs may offer therapeutic benefits for CRPC patients.
  • Further research into AR-V targeted therapies is warranted for CRPC treatment.

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