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Updated: Feb 8, 2026

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Central giant cells lesion: Report of a conservative management
Marina Rolo Pinheiro da Rosa1, Juliana Lopes de Sá2, Valber Barbosa Martins3
1Resident of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Amazon State University, Manaus, Brazil.
Abstract:
Central giant cells lesion (CGCL) is defined as a benign intraosseous destructive pathology. It is classified as aggressive or nonaggressive, depending on their clinical, imaginologic, and histological behavior. The behavior, location, and extension of the lesion added to the patient's age will determine the choice of the treatment, either surgical or clinical. Thereby, the aim of this work is to review the literature related to the CGCL, as well as to present a clinical case report of a 22-year-old female patient, affected with an injury on the left side of her jaw. After the diagnosis, it was decided to carry out a conservative treatment with intralesional injections of triamcinolone (10 mg/ml). The injections were performed once a week for 6 weeks. The progress of the patient was satisfactory, and after 4 years, it has been observed through imaging and clinical bone formation examinations with complete remission of the injury and no signs of recurrence.
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