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Updated: Feb 8, 2026

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Failure of ceftolozane-tazobactam salvage therapy in complicated pneumonia with lung abscess
Paul O Lewis1, David B Cluck2, Jennifer L Tharp1
1Department of Pharmacy Johnson City Medical Center Johnson City TN USA.
Abstract:
Treatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane-tazobactam. We report a treatment failure with ceftolozane-tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane-tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection.
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