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Updated: Feb 8, 2026

Neutrophil Isolation Protocol
Published on: July 23, 2008
Cyclic thrombocytopenia with statistically significant neutrophil oscillations
Gabriel P Langlois1, Donald M Arnold2, Jayson Potts3
1Division of Applied Mathematics Brown University Providence RI USA.
Abstract:
Cyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used successfully in immune thrombocytopenia. A precise diagnosis must establish the statistical significance of periodicity of the platelet counts using statistical methods (eg, Lomb-Scargle periodogram).
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