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An Orthotopic Model of Murine Bladder Cancer
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The aging bladder insights from animal models.

Lori A Birder1,2, Aura F Kullmann2, Christopher R Chapple3

  • 1University of Pittsburgh School of Medicine, Department of Pharmacology, Pittsburgh, PA, USA.

Asian Journal of Urology
|July 11, 2018
PubMed
Summary
This summary is machine-generated.

Aging commonly alters bladder function, leading to increased lower urinary tract symptoms (LUTS). This review explores the prevalence and underlying neural mechanisms contributing to LUTS in the aging bladder.

Keywords:
AgingBladder functionEtiology of lower urinary tract symptomsLower urinary tract symptoms

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Area of Science:

  • Gerontology
  • Urology
  • Neuroscience

Background:

  • Bladder function alterations are common with aging.
  • The aging population is growing, increasing the prevalence of related healthcare issues.
  • Lower urinary tract symptoms (LUTS) significantly impact quality of life in older adults.

Purpose of the Study:

  • To review the prevalence of lower urinary tract symptoms (LUTS) in aging individuals.
  • To discuss potential mechanisms underlying age-related LUTS.
  • To highlight the complex neural changes affecting the aging bladder.

Main Methods:

  • Literature review of laboratory studies.
  • Analysis of age-related changes in bladder innervation.
  • Synthesis of current understanding of LUTS pathophysiology in aging.

Main Results:

  • LUTS prevalence increases significantly with age.
  • Age-related changes in neural innervation are key factors.
  • Complex interactions within the bladder's neural network contribute to dysfunction.

Conclusions:

  • Aging involves intricate neural alterations in the bladder.
  • These neural changes are strongly linked to the development of LUTS.
  • Understanding these mechanisms is crucial for managing age-related bladder dysfunction.