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Updated: Feb 8, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Peptide nucleic acid mediated inhibition of the bacterial signal recognition particle
Sudipta Ghosh1, Snehlata Saini, Ishu Saraogi
1Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462066, MP, India. ishu@iiserb.ac.in.
Abstract:
We have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.
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