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Endoplasmic reticulum stress and kidney dysfunction

Morgan Gallazzini1,2, Nicolas Pallet1,2,3,4,5

  • 1INSERM U1151 - CNRS UMR 8253, Institut Necker Enfants Malades, Paris, France.

Biology of the Cell
|July 11, 2018
PubMed

Insights

Endoplasmic reticulum (ER) stress is implicated in kidney injury, contributing to both damage and adaptation in acute kidney injury (AKI) and chronic kidney disease (CKD). This review analyzes ER stress

Area of Science:

  • Nephrology
  • Molecular Biology
  • Cellular Biology

Background:

  • Chronic kidney disease (CKD) is a global health issue requiring better therapeutic strategies.
  • Acute kidney injury (AKI) significantly contributes to chronic histological damage in CKD.
  • Cellular responses to kidney injury involve microenvironmental changes and adaptive processes.

Purpose of the Study:

  • To review the role of endoplasmic reticulum (ER) stress in AKI and CKD pathophysiology.
  • To critically analyze evidence linking ER stress to kidney damage.
  • To explore ER stress's dual role in kidney injury and protection.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of molecular and cellular mechanisms.
  • Synthesis of current evidence on ER stress in kidney disease.

Main Results:

  • ER stress is a common cellular response to kidney injury.
  • ER stress contributes to both acute and chronic kidney damage.
  • ER stress also plays a role in cellular adaptation and nephroprotection.

Conclusions:

  • ER stress is a key mediator in the pathophysiology of AKI and CKD.
  • Understanding ER stress mechanisms is crucial for developing novel therapeutic interventions.
  • Further research is needed to fully elucidate ER stress's complex role in kidney health and disease.
Keywords:
acute kidney injurychronic kidney diseaseendoplasmic reticulum stressproteinuriaunfolded protein response

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