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Updated: Feb 8, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial
T Fonnes1,2, J Trovik1,2, P-Hd Edqvist3,4
1Department of Clinical Science, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.
Objective:
Correct preoperative identification of high-risk patients is important to optimise surgical treatment and improve survival. We wanted to explore if asparaginase-like protein 1 (ASRGL1) expression in curettage could predict lymph node metastases and poor outcome, potentially improving preoperative risk stratification.
Design:
Multicentre study.
Setting:
Ten hospitals in Norway, Sweden and Belgium.
Population:
Women diagnosed with endometrial carcinoma.
Methods:
ASRGL1 expression in curettage specimens from 1144 women was determined by immunohistochemistry.
Main Outcome Measures:
ASRGL1 status related to disease-specific survival, lymph node status, preoperative imaging parameters and clinicopathological data.
Results:
ASRGL1 expression had independent prognostic value in multivariate survival analyses, both in the whole patient population (hazard ratio (HR) 1.63, 95% CI 1.11-2.37, P = 0.012) and in the low-risk curettage histology subgroup (HR 2.54, 95% CI 1.44-4.47, P = 0.001). Lymph node metastases were more frequent in women with low expression of ASRGL1 compared with women with high ASRGL1 levels (23% versus 10%, P < 0.001), and low ASRGL1 level was found to independently predict lymph node metastases (odds ratio 2.07, 95% CI 1.27-3.38, P = 0.003).
Conclusions:
Low expression of ASRGL1 in curettage independently predicts lymph node metastases and poor disease-specific survival.
Tweetable Abstract:
Low ASRGL1 expression in curettage predicts lymph node metastasis and poor survival in endometrial carcinoma.
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