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Updated: Feb 8, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

419

New options on the horizon for nononcogene addicted non-small-cell lung cancer

Luca Paglialunga1, Serena Ricciardi2, Manolo D'Arcangelo3

  • 1AOU Careggi, Department of Medical Oncology, Florence, Italy.

Future Oncology (London, England)
|July 11, 2018
PubMed

Insights

New biological agents offer updated treatment options for non-small-cell lung cancer (NSCLC) without driver mutations. This review provides a therapeutic algorithm to guide clinical decisions for these patients.

Area of Science:

  • Oncology
  • Medical treatment

Background:

  • Traditional non-small-cell lung cancer (NSCLC) treatment relies on chemotherapy.
  • Treatment options for NSCLC lacking driver mutations have stagnated.
  • Recent years introduced novel biological agents for NSCLC care.

Purpose of the Study:

  • To review recent advancements in treating NSCLC without targetable driver mutations.
  • To provide an updated therapeutic algorithm for clinical practice.

Main Methods:

  • Literature review of recent clinical trials and approvals.
  • Synthesis of data on immune checkpoint inhibitors and antiangiogenic drugs.
  • Development of a treatment algorithm based on current evidence.

Main Results:

  • Significant progress in NSCLC treatment beyond chemotherapy.
  • Emergence of immune checkpoint inhibitors and antiangiogenic therapies.
  • Availability of new options for non-oncogene-addicted NSCLC.

Conclusions:

  • Novel biological agents are transforming NSCLC treatment.
  • A structured therapeutic algorithm can optimize treatment selection.
  • Further research is needed to refine treatment strategies for NSCLC.
Keywords:
NSCLCimmune checkpoint inhibitorstherapeutic algorithm

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