Related Experiment Video

Updated: Feb 8, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

419

Immunotherapy in non-small-cell lung cancer: a bridge between research and clinical practice

Francesco Passiglia1, Oriana Commendatore2, Milena Vitali3

  • 1Department of Surgical, Oncological & Stomatological Disciplines, University of Palermo, 90100 - Palermo, Italy.

Future Oncology (London, England)
|July 11, 2018
PubMed

Insights

Lung cancer was thought to be poorly immunogenic, but immune checkpoint inhibitors show promise. This review covers cancer immunity, non-small cell lung cancer, and immunotherapy biomarkers.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Lung cancer historically viewed as poorly immunogenic.
  • Limited efficacy of traditional immunomodulating strategies.
  • Recent advances in understanding cancer immune evasion.

Purpose of the Study:

  • Review the basis of cancer immunogenicity and immune escape, focusing on non-small cell lung cancer (NSCLC).
  • Summarize mechanisms of immune checkpoint inhibitors (ICIs).
  • Define unmet needs in NSCLC immunotherapy.

Main Methods:

  • Literature review of cancer immunology and NSCLC.
  • Analysis of molecular mechanisms of immune evasion.
  • Review of clinical efficacy and biomarker data for ICIs.

Main Results:

  • Immune checkpoint inhibitors demonstrate significant clinical benefits in a subset of NSCLC patients.
  • Understanding molecular pathways has enabled development of novel immunotherapies.
  • Biomarkers are crucial for predicting ICI response.

Conclusions:

  • ICIs have revolutionized NSCLC treatment by reactivating host immune responses.
  • Further research is needed to identify predictive biomarkers and overcome resistance.
  • Addressing unmet needs in immunotherapy is critical for improving patient outcomes.
Keywords:
NSCLCPD-1PD-L1biomarkerscancer immunogenicityclinical studiesimmune checkpoint inhibitorstranslational research

More Related Videos

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients07:43

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

11.0K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Related Concept Videos

Design Example: Strain Gauge Bridge or Wheatstone Bridge01:15

Design Example: Strain Gauge Bridge or Wheatstone Bridge

The utilization of strain gauges as transducers for converting mechanical strain into electrical signals is a common practice in various engineering applications. These strain gauges are frequently integrated into Wheatstone bridge circuits to accurately measure parameters such as force or pressure. Within this context, each element within the circuit exhibits a resistance that undergoes subtle variations when subjected to mechanical strain. The primary objective is to convert minuscule...
1.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Wheatstone Bridge01:29

Wheatstone Bridge

An ohmmeter is a resistance-measuring device. It works by applying a voltage to a resistor of unknown resistance and measuring the current across the resistor. The resistance value is deduced using Ohm's law. Usually, the standard configuration of an ohmmeter comprises a voltmeter or an ammeter. However, such configurations are limited in accuracy because the meters alter the voltage applied to the resistor and the current that flows through it.
Thus, for accurate resistance measurements, a...
1.2K
Bridge rectifier01:24

Bridge rectifier

The bridge rectifier is essential in electronics for efficiently converting alternating current (AC) to direct current (DC). Comprised of four diodes configured in a bridge layout, this rectifier effectively processes both the positive and negative halves of the AC waveform, making it superior to half-wave and full-wave center-tapped rectifiers in terms of voltage regulation and output stability.
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
1.6K
Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
122.9K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K