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[Bispecific Antibodies: Formats and Areas of Application]

E A Vasilenko1, V V Mokhonov1, E N Gorshkova1

  • 1Nizhny Novgorod State University, Nizhny Novgorod, 603950 Russia.

Molekuliarnaia Biologiia
|July 11, 2018
PubMed

Bispecific antibodies capable of simultaneously binding two targets have been studied for many years with a view to their implementation in clinical practice. Unique biological and pharmacological properties, as well as the diversity of their formats, make it possible to consider bispecific antibodies as promising agents for use in various procedures: from visualization of intracellular processes to targeted anticancer therapy. Bispecific antibodies help to determine more precisely the therapeutic target, thereby increasing the efficiency of therapy and reducing the probability of side effects. The present review describes the main formats of bispecific antibodies, methods for their generation, and possibilities for practical application.

Keywords:
bispecific antibodygene engineeringselective therapy

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