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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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Cell membrane electroporation modeling: A multiphysics approach.

Ezequiel Goldberg1, Cecilia Suárez2, Mauricio Alfonso3

  • 1Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Buenos Aires, Argentina.

Bioelectrochemistry (Amsterdam, Netherlands)
|July 11, 2018
PubMed
Summary
This summary is machine-generated.

This study presents a multiphysics model for electric pulse-cell membrane interactions. The model reveals that cell membrane deformation during electroporation impacts pore formation and ion transport, aligning with experimental data.

Keywords:
ElectrochemotherapyElectroporationIon transportMathematical modelingMembrane deformation

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Area of Science:

  • Biophysics
  • Biotechnology
  • Medical Engineering

Background:

  • Electroporation uses electric pulses to perturb cell membranes, crucial in medicine and biotech.
  • The precise interaction between electric pulses and cell membranes remains incompletely understood and formalized.

Purpose of the Study:

  • To develop and present a comprehensive Multiphysics (MP) model for electric pulse-cell membrane interactions.
  • To elucidate the physical mechanisms governing electroporation at the cellular level.

Main Methods:

  • Developed an MP model integrating Poisson equation (electric field), Nernst-Planck equations (ion transport), Maxwell tensor and mechanical equilibrium (membrane deformation), and Smoluchowski equation (permeabilization).
  • Explicitly discretized the cell membrane for detailed mechanical analysis.

Main Results:

  • The MP model predicts elastic deformation of the cell membrane during electric pulses.
  • This deformation influences transmembrane potential, pore creation dynamics, and ion transport.
  • Predicted a coincidence between maximum membrane deformation, pore aperture, and ion uptake.

Conclusions:

  • The developed MP model provides a formalized understanding of electric pulse-cell membrane interactions.
  • Membrane deformation is a key factor influencing electroporation outcomes.
  • Model predictions are experimentally validated in various cell types and lipid vesicles.