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Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
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Cerebral blood flow modulations during proactive control in chronic hypotension
Stefan Duschek1, Alexandra Hoffmann1, Angela Bair1
1UMIT - University of Health Sciences Medical Informatics and Technology, Institute of Psychology, Eduard-Wallnöfer-Zentrum 1, 6060 Hall in Tirol, Austria.
Brain and Cognition
|July 11, 2018
Summary
Chronic low blood pressure (hypotension) impairs cognitive function by reducing cerebral blood flow adjustments during proactive control tasks. This suggests a general deficit in attention and processing speed linked to hemodynamic dysregulation.
Area of Science:
- Neuroscience
- Cardiovascular Physiology
- Cognitive Psychology
Background:
- Chronic low blood pressure (hypotension) is linked to cognitive deficits, potentially due to impaired cerebral blood flow regulation.
- Proactive control, essential for readiness, may be particularly affected in hypotensive individuals.
Purpose of the Study:
- To investigate cerebral blood flow modulations during proactive control in individuals with hypotension.
- To compare cognitive performance and cerebral hemodynamics between hypotensive and normotensive participants.
Main Methods:
- Functional transcranial Doppler sonography (fNIRS) was used to measure middle cerebral artery blood flow velocities.
- A precued Stroop task was employed to assess proactive control and executive function load.
- Participants included 40 hypotensive and 40 normotensive individuals.
Main Results:
- Hypotensive participants showed reduced bilateral blood flow increases during response preparation.
- Response times were longer in hypotensive individuals compared to normotensive controls.
- Group differences in blood flow and response time were consistent across varying executive function loads.
Conclusions:
- Hypotension is associated with impaired cerebral blood flow adjustment during proactive control.
- Findings suggest a general deficit in attentional function and processing speed in hypotension, linked to cerebral hemodynamic dysregulation.
Keywords:
Blood pressureCerebral blood flowHypotensionProactive controlTranscranial Doppler sonographyMore Related Videos
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