Peripheral facial paralysis associated with HIV infection: A case series and literature review

Pornchai Sathirapanya1, Chris Fujitnirun1, Suwanna Setthawatcharawanich1

  • 1Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110 Thailand.

Abstract

Insights

Peripheral facial paralysis (PFP) in HIV patients often presents later and in a unilateral form, with most patients experiencing good recovery. This study clarifies the association between PFP and HIV status, co-morbidities, and outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Peripheral facial paralysis (PFP) association with Human Immunodeficiency Virus (HIV) infection is not well-understood.
  • HIV infection can present with various neurological complications, including facial nerve palsy.

Purpose of the Study:

  • To describe the association between PFP and HIV infection status.
  • To analyze related co-morbidities and outcomes of PFP in HIV-infected individuals.
  • To conduct a literature review on PFP in the context of HIV infection.

Main Methods:

  • Retrospective review of HIV-infected patients with PFP from January 2002 to June 2015.
  • Summarization of demographic data, clinical characteristics, HIV co-morbidities, and PFP outcomes.
  • Comparative analysis with literature data using descriptive statistics and Mann-Whitney U test (p < 0.05).

Main Results:

  • Sixteen patients (6 males, 10 females) were included; median age was 46 years, higher than literature (p=0.004).
  • Median CD4 count was 274 cells/μL, non-significantly lower than literature (p=0.058).
  • Unilateral PFP (UFP) was most frequent in this series, occurring later after HIV diagnosis; bilateral PFP (BFP) was common in literature, often simultaneous with diagnosis.

Conclusions:

  • HIV-associated PFP in this series featured older patients, lower CD4 counts, and later onset compared to literature.
  • Most cases, particularly UFP without HIV complications, showed satisfactory recovery.
  • Findings highlight variations in PFP presentation and outcomes based on HIV status and co-morbidities.

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