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Correlation Between Resistin Level and Metabolic Syndrome Component: A Review
Mostafa Mostafazadeh1,2, Sanya Haiaty2,3, Ali Rastqar4,5
1Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 11, 2018
Summary
Resistin
Area of Science:
- Endocrinology and Metabolism
- Molecular Biology
Background:
- Metabolic syndrome (MetS) is a cluster of conditions increasing risks for critical diseases.
- Resistin is implicated in MetS pathologies, but its precise role remains unclear.
Purpose of the Study:
- To review and compare resistin's effects on Metabolic syndrome components across human and mammalian studies.
- To evaluate resistin's contribution to MetS initiation and progression.
Main Methods:
- Systematic literature search of PubMed, Science Direct, and Scopus.
- Inclusion of human and animal studies investigating resistin and MetS components.
- Analysis of clinical and experimental data.
Main Results:
- No significant correlation found between resistin and fasting blood glucose (FBG) in various human groups.
- Inconsistent results reported for resistin's correlation with triglycerides (TG), HDL cholesterol, and abdominal obesity.
- Variability in findings attributed to sample size, genetic background, gender, and study design.
Conclusions:
- The exact role of resistin in Metabolic syndrome requires further investigation.
- Inconsistencies highlight the need for standardized research methodologies.
- Systematic reviews and meta-analyses are essential for definitive conclusions on resistin's impact on MetS.
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