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Updated: Feb 8, 2026

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
Published on: August 31, 2022
Low- and high-intensity one-week occlusion training improves muscle oxygen consumption and reduces muscle fatigue
Kestutis Bunevicius1, Albinas Grunovas1, Eugenijus Trinkunas1
1Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.
Background:
Low-intensity resistance exercises with blood flow restriction have been shown is effective to increase muscular strength and hypertrophy. However, the effects of combined training: one-week occlusion training with various exercise intensities by using less occlusion pressure on muscle strength improvement, fatigability and their work capacity are not clear.
Methods:
Participants (N.=24) were middle-distance runners with 4-6 years of training experience. A control group without blood flow restriction (N.=12, age 23±1 years) and an experimental group with blood flow restriction (N.=12, age 22±1 years). In this study, the calf muscles were impacted by the training with occlusion 120 mmHg. We used intensive one-week daily training, whereby exercise intensity was gradually increased daily from 20% to 80% of maximal voluntary contraction (MVC) and then decreased to 60% by the end of the week.
Results:
MVC of foot flexion muscles after the one-week occlusion training in the experimental group and control group increased (P<0.05) by 5.6±1.3% and 5.3±1.2%, respectively. Meanwhile in experimental group work capacity improved only 2.4±3.5% (P>0.05) and in control group it significantly decreased 11.8±2.5% (P<0.05). StO2 decreased during exercise test from the baseline 100% to 45.2±4.3% before occlusion training and to 34.6±6.2% after the week of occlusion training (P<0.05).
Conclusions:
Intensive one-week training with occlusion with varying intensity improves resistance to fatigue and recovery after training. This kind of training improves oxygen consumption while exercising.
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