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Evaluating Twitter as a complementary data source for pharmacovigilance.

Jérémy Lardon1,2,3,4, Florelle Bellet5, Rim Aboukhamis6

  • 1a Sorbonne Université , UPMC Université Paris 06, UMR_S 1142, LIMICS , Paris , France.

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Twitter data can supplement drug safety monitoring. A study found that over 8% of tweets mentioned adverse drug reactions (ADRs), with some indicating unexpected or serious events, highlighting social media

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Area of Science:

  • Pharmacovigilance and Drug Safety
  • Social Media Analytics
  • Public Health Surveillance

Background:

  • Social media platforms are increasingly recognized as potential sources for drug safety surveillance.
  • Understanding the frequency and utility of adverse drug reaction (ADR) reporting on platforms like Twitter is crucial.
  • Character limitations on social media posts present unique challenges for detailed pharmacovigilance data collection.

Purpose of the Study:

  • To quantify the incidence of adverse drug reactions (ADRs) reported by Twitter users.
  • To assess the value and informativeness of tweets as a data source for pharmacovigilance.
  • To explore the feasibility of using social media data for drug safety monitoring despite inherent limitations.

Main Methods:

  • Extraction of tweets related to 33 monitored drugs using the Twitter Streaming API.
  • Data collection period: September 30, 2014, to April 5, 2015.
  • Manual classification of tweets by two pharmacovigilance centers to identify potential ADR case reports.

Main Results:

  • Out of 10,534 analyzed tweets, 8.05% mentioned or implied an ADR.
  • 2.74% of tweets were classified as potential ADR case reports.
  • Among case reports, 7.27% involved unexpected ADRs and 11.42% involved serious ADRs.

Conclusions:

  • Twitter can serve as a supplementary data source for pharmacovigilance with dedicated tools.
  • Causality assessment remains a significant limitation for individual ADR reports from tweets.
  • The increased character limit (280 characters) may enhance the informativeness of future ADR reporting on Twitter.