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Drug transporters and anthracycline-induced cardiotoxicity

Kevin M Huang1, Shuiying Hu1, Alex Sparreboom1

  • 1Division of Pharmaceutics & Pharmaceutical Chemistry, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

Pharmacogenomics
|July 12, 2018
PubMed

Insights

Solute carrier transporters affect drug absorption and elimination. Genetic variations in these transporters influence susceptibility to drug toxicity and interactions, impacting treatment outcomes.

Area of Science:

  • Pharmacology
  • Genetics
  • Biochemistry

Background:

  • Solute carrier (SLC) transporters are crucial for drug absorption and elimination.
  • Tissue-specific SLC expression impacts drug response and toxicity.
  • Genetic variants in SLCs can alter drug transport and efficacy.

Purpose of the Study:

  • To review the role of SLC transporters in anthracycline-induced cardiotoxicity.
  • To highlight the implications of genetic variants on drug response.
  • To discuss novel technologies for studying anthracycline transport.

Main Methods:

  • Literature review of recent advances in SLC transporter research.
  • Analysis of studies on genetic variants and their functional impact.
  • Discussion of emerging technologies for transport mechanism investigation.

Main Results:

  • SLC transporters play a significant role in anthracycline cardiotoxicity.
  • Genetic variations in SLCs are associated with altered anthracycline efficacy and toxicity.
  • Novel technologies offer new insights into SLC-mediated drug transport.

Conclusions:

  • Understanding SLC transporter function and genetics is vital for personalized medicine.
  • Targeting SLCs may offer strategies to mitigate drug-induced toxicity.
  • Further research using advanced technologies will elucidate SLC-mediated drug effects.
Keywords:
anthracyclinescardiomyocytescardiotoxicitydoxorubicinorganic cation transporterssolute carriers

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