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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
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Published on: November 25, 2022

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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

Iryna Prots1, Janina Grosch2, Razvan-Marius Brazdis3

  • 1Department of Stem Cell Biology, Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany; iryna.prots@uk-erlangen.de.

Proceedings of the National Academy of Sciences of the United States of America
|July 12, 2018
PubMed
Summary

Alpha-synuclein (α-Syn) oligomers disrupt axonal transport and cause energy deficits in human neurons. This study identifies these toxic α-Syn oligomers as key drivers of early axonal dysfunction in synucleinopathies.

Keywords:
axonal transportneurodegenerationoligomerssynucleinopathiesα-synuclein

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