Gastrointestinal CMV Disease and Tuberculosis in an AIDS Patient: Synergistic Interaction between Opportunistic
Miriã Boaretto Teixeira Fernandes1, Pedro Afonso Nogueira Moisés Cardoso1, Luiza Bassani Altoé1
1Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ, Brazil.
Abstract:
The AIDS pandemic has made diseases such as tuberculosis, CMV disease, and other opportunistic infections more prevalent; these diseases may even be found to be associated among themselves, and the natural history of each disease may present in an unusual manner. We report the case of a 41-year-old man with HIV (CD4 of 144 cells/dL) and HCV with hematochezia due to tuberculosis in the ileocecal valve and descending colon and CMV tissue invasive disease in the esophagus and descending colon. Coinfection among tuberculosis and cytomegalovirus in the gastrointestinal tract was described only once in a patient with a recent diagnosis of HIV that affected the distal ileum and ascending colon. We will discuss the peculiarities of the case and the behavior of the immune system in the face of simultaneous opportunistic infections. This is a challenging scenario that has scarce publications and is of great clinical importance.
Insights
This case report details a patient with HIV and HCV experiencing simultaneous gastrointestinal tuberculosis and cytomegalovirus disease. It highlights unusual presentations of opportunistic infections in immunocompromised individuals.
Area of Science:
- Infectious Diseases
- Immunology
- Gastroenterology
Background:
- The AIDS pandemic increases opportunistic infections like tuberculosis (TB) and cytomegalovirus (CMV) disease.
- These infections can co-occur and present atypically in individuals with human immunodeficiency virus (HIV).
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