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Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis
Ahmet Basturk1, Reha Artan1, Aygen Yılmaz1
1Department of Pediatric Gastroenterology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Insights
Upper gastrointestinal system (GIS) involvement, particularly gastritis, is significantly more prevalent in pediatric patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), compared to those without IBD.
Area of Science:
- Pediatric gastroenterology
- Histopathology
- Inflammatory Bowel Disease (IBD) research
Background:
- Inflammatory Bowel Disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), primarily affects the lower gastrointestinal tract.
- However, upper gastrointestinal system (GIS) involvement in pediatric IBD patients requires further investigation.
Purpose of the Study:
- To determine the prevalence and characteristics of upper GIS involvement in pediatric patients diagnosed with CD, UC, and non-IBD.
- To compare the upper GIS findings between IBD subtypes and non-IBD controls.
Main Methods:
- Pediatric patients (2-18 years) with suspected IBD underwent esophagogastroduodenoscopy (EGD) and colonoscopy.
- Histopathological examination of EGD samples (duodenum, antrum, corpus, esophagus) identified gastritis, duodenitis, and esophagitis.
- Data were compared between IBD (CD, UC) and non-IBD groups.
Main Results:
- Upper GIS involvement was detected in 94.1% of IBD patients versus 38.5% in non-IBD controls (p=0.032).
- Gastritis was significantly more common in CD (93.8%) and UC (76.8%) patients compared to non-IBD patients (38.5%) (p=0.03 for CD, p=0.047 for UC).
- No significant difference in upper GIS findings was observed between CD and UC groups.
Conclusions:
- Pediatric patients with CD and UC exhibit significantly higher rates of upper gastrointestinal gastritis compared to non-IBD pediatric patients.
- These findings highlight the importance of considering upper GI endoscopy in the diagnostic workup of pediatric IBD.
Purpose:
The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences.
Methods:
This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined.
Results:
In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03).
Conclusion:
The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.
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