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Updated: Feb 8, 2026

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Proteomic profile of patients with atrial fibrillation undergoing cardiac surgery

Ilias P Doulamis1, George Samanidis2, Aspasia Tzani1

  • 1Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Interactive Cardiovascular and Thoracic Surgery
|July 12, 2018
PubMed

Insights

Growth/differentiation factor 15 and resistin show promise as biomarkers for atrial fibrillation (AF) risk in cardiovascular disease patients. Further proteomic research is needed to confirm their role and explore underlying molecular pathways.

Area of Science:

  • Cardiovascular Medicine
  • Proteomics
  • Biomarker Discovery

Background:

  • Atrial fibrillation (AF) is a common complication in patients with cardiovascular disease.
  • Identifying reliable biomarkers for AF risk stratification is crucial for patient management.

Purpose of the Study:

  • To identify potential proteomic biomarkers for atrial fibrillation (AF) in patients with advanced cardiovascular disease.
  • To evaluate the predictive capacity of serum protein levels for AF.

Main Methods:

  • Proteomic analysis of serum samples from 123 cardiac surgery patients (22 with AF, 101 without AF) and 20 healthy controls.
  • Measurement of 22 specific proteins, including growth/differentiation factor 15 and resistin.
  • Statistical analysis using linear models and Matthews Correlation Coefficient; combined markers assessed with Support Vector Machines.

Main Results:

  • Serum levels of most measured proteins were higher in cardiovascular disease patients than in healthy subjects.
  • Growth/differentiation factor 15 and resistin were significantly elevated in patients with AF compared to those without AF (P=0.029 and P=0.007, respectively).
  • Certain biomarker pairs demonstrated moderate predictive capability for AF.

Conclusions:

  • Growth/differentiation factor 15 and resistin may aid in stratifying AF risk among cardiovascular disease patients.
  • Further proteomic research and investigation into molecular pathways are warranted to validate these findings.
Abstract

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