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Impaired ankle-brachial index in antiphospholipid syndrome: Beyond the traditional risk factors

Simona Caraiola1,2, Ciprian Jurcut3, Alina Dima1,2

  • 1Department of Internal Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Journal of Clinical Laboratory Analysis
|July 12, 2018
PubMed

Insights

Antiphospholipid syndrome (APS) patients have higher atherosclerosis risk. Anti-beta 2-glycoprotein I (aβ2GPI) IgG antibodies predict abnormal ankle-brachial index (ABI), a marker of atherosclerosis, in these patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Antiphospholipid syndrome (APS) is linked to an elevated risk of atherosclerosis.
  • Atherosclerosis, a hardening of the arteries, poses significant cardiovascular risks.

Purpose of the Study:

  • To identify predictors of an abnormal ankle-brachial index (ABI) in APS patients.
  • The ABI serves as a surrogate marker for atherosclerosis, assessing peripheral artery disease.

Main Methods:

  • Ankle-brachial index (ABI) was measured in 106 APS patients.
  • Cardiovascular risk factors were evaluated, and APS-associated antibodies were determined in 73 patients.

Main Results:

  • 28.3% of APS patients exhibited a low ABI, indicating atherosclerosis.
  • Higher titers of anti-beta 2-glycoprotein I (aβ2GPI) IgG antibodies were associated with abnormal ABI.
  • Multivariate analysis confirmed aβ2GPI IgG as an independent predictor of low ABI (P=0.04).

Conclusions:

  • Anti-beta 2-glycoprotein I (aβ2GPI) IgG antibodies are associated with impaired ABI in antiphospholipid syndrome (APS).
  • This association suggests a potential role for aβ2GPI IgG in the pathogenesis of atherosclerosis within APS patients.
Abstract

Keywords:
ankle-brachial indexantiphospholipid syndromebeta-2 glycoprotein Icardiovascular risk

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