Related Experiment Video

Updated: Feb 8, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K

A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation

Diana Swolin-Eide1, Sverker Hansson1, Per Magnusson2

  • 1Department of Pediatrics, Institute for Clinical Sciences, The Queen Silvia Children's Hospital, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

Pediatric Transplantation
|July 12, 2018
PubMed

Insights

Kidney transplantation positively impacts pediatric growth, improving height and BMI. Bone formation markers increased, indicating favorable bone acquisition after transplantation.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Kidney transplantation is crucial for pediatric patients with end-stage renal disease.
  • Long-term effects on growth and skeletal development require further investigation.

Purpose of the Study:

  • To evaluate growth and skeletal development in pediatric kidney transplant recipients over three years.
  • To assess changes in bone metabolism markers, parathyroid hormone (PTH), and vitamin D levels.

Main Methods:

  • Prospective study of pediatric patients (3.4-15.0 years) post-kidney transplantation.
  • Serial assessments of growth (height SDS, BMI SDS), body composition, bone mineral density (BMD), bone turnover markers (CTX, TRACP5b, PINP, ALP, osteocalcin), PTH, and vitamin D.
  • Measurements taken at baseline, 3, 12, and 36 months post-transplant.

Main Results:

  • Significant increases in height SDS (from -1.7 to -1.1) and BMI SDS (from -0.1 to 0.6) over 3 years.
  • Increased fat and lean mass, with total body bone mineral content (BMC) increasing.
  • Decreased bone resorption markers initially, followed by increased bone formation markers over time.
  • No significant changes in total BMD observed.

Conclusions:

  • Kidney transplantation promotes favorable growth and bone acquisition in pediatric patients.
  • Improved height and BMI, along with enhanced bone formation, suggest positive long-term skeletal health outcomes.

Keywords:
body compositionbone markersbone mineral densitydual-energy X-ray absorptiometrygrowthpediatric kidney transplantation

More Related Videos

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.8K
A Modified Surgical Technique for Kidney Transplantation in Mice10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

7.2K

Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
533
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
492
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.4K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
430
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
402
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
845