Relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney...

Area of Science:

• Nephrology
• Cardiology
• Biomarkers

Background:

• Diastolic dysfunction (DD) is a significant contributor to cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients.
• Non-traditional risk factors, including arterial stiffness and inflammation, are implicated in the development of DD in CKD.
• Understanding these associations is crucial for managing CVD risk in CKD.

Purpose of the Study:

• To investigate the relationship between inflammatory markers (IL-12, IL-18, hsCRP) and arterial stiffness (24-h pulse pressure) with DD.
• To assess these associations in patients with stages 3-4 CKD.
• To identify potential non-traditional risk factors for DD in this population.

Main Methods:

• A sub-analysis of 78 non-diabetic patients with stages 3-4 CKD was conducted.
• The study examined the association between 24-h pulse pressure (PP), interleukin (IL)-12, IL-18, and highly sensitive C-reactive protein (hsCRP) with DD.
• Statistical analyses were performed to determine significant relationships, including adjustments for age.

Main Results:

• Diastolic dysfunction (DD) was identified in 49% of the study cohort.
• Patients with DD were older and exhibited higher 24-h pulse pressure (PP).
• While 24-h PP showed an initial association with DD, it was not significant after adjusting for age. Inflammatory markers (IL-12, IL-18, hsCRP) were not significantly different between groups.

Conclusions:

• Subclinical DD is prevalent in approximately 50% of patients with moderate-stage CKD.
• No significant association was found between DD and the measured inflammatory markers (IL-12, IL-18, hsCRP).
• The association between 24-h PP and DD was confounded by age, highlighting the need for larger studies in diverse CKD populations.