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Updated: Feb 8, 2026

Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells
Published on: October 20, 2023
Hydrogen peroxide modulates redox status, energy metabolism, and gene expression in a dose- and time-dependent manner
Omar A Ahmed-Farid1, Hanan A Rizk2, Ahmed M Shehata1
1Physiology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
Aim:
The aim of this study was to investigate the effect of three different hydrogen peroxide (H2 O2 ) levels on blood and liver oxidative status, energy metabolites, and gene expression in male albino rats at two time intervals (2 and 4 weeks).
Methods:
A total of 32 rats were divided into four groups. The first group received tap water and served as control. The second group received low dose of hydrogen peroxide (H2 O2 ; 0.25%), The third group received medium dose of H2 O2 (0.5%) and the fourth group received high dose of H2 O2 (1%) in drinking water.
Results:
Present data showed that medium and high dose increased oxidative stress markers, decreased cell energy, and decreased antioxidant enzyme gene expression (GPx and Nrf2) and its downstream in contrast low dose did not show significant effects.
Conclusion:
This study might indicate that hydrogen peroxide medium level is the best dose for redox model status.
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