Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

HOXA11 antisense long noncoding RNA (HOXA11-AS): A promising lncRNA in human cancers

Cheng-Wei Lu1, Dan-Dan Zhou2, Tian Xie3

  • 1Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.

Cancer Medicine
|July 12, 2018
PubMed

Insights

Long noncoding RNA HOXA11-AS (NCRNA00076) is implicated in various human cancers, acting as both a tumor suppressor and accelerator. Its aberrant expression and mechanisms in tumorigenesis highlight its potential as a diagnostic biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Cancers represent a leading global cause of mortality, with high morbidity rates.
  • Long noncoding RNAs (lncRNAs) are crucial regulators of biological processes, including cancer development.
  • HOXA11-AS (NCRNA00076) is a novel lncRNA identified in 2009, originating from the antisense strand of the HOXA11 gene.

Purpose of the Study:

  • To review and summarize current research on the expression and function of HOXA11-AS in human malignancies.
  • To detail the diverse roles of HOXA11-AS as either a tumor suppressor or accelerator across various cancer types.
  • To explore the underlying molecular mechanisms of HOXA11-AS in tumorigenesis and cancer progression.

Main Methods:

  • Literature review of advanced research on HOXA11-AS expression and function in human cancers.
  • Compilation and analysis of studies detailing HOXA11-AS mechanisms in specific malignancies.
  • Synthesis of findings related to HOXA11-AS's role in cancer networks.

Main Results:

  • HOXA11-AS expression is aberrantly altered in numerous cancers, influencing tumor progression.
  • Specific examples include nonsmall cell lung cancer, osteosarcoma, uveal melanoma, glioma, hepatocellular carcinoma, gastric cancer, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, and glioblastoma.
  • HOXA11-AS participates in complex cancer networks, affecting tumorigenesis and progression.

Conclusions:

  • HOXA11-AS plays a significant role in the initiation and advancement of various human cancers.
  • Aberrantly expressed HOXA11-AS presents potential as a biomarker for early cancer detection and prognosis.
  • Targeted interventions involving HOXA11-AS may offer novel therapeutic strategies for cancer management.
Keywords:
HOXA11-ASlong noncoding RNAstumor acceleratortumor suppressortumorigenesis

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.2K
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K