Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.6K
4.6K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.8K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Miniature NAD<sup>+</sup>-II riboswitches control bacterial genes for nicotinamide salvage and de novo NAD<sup>+</sup> biosynthesis.

RNA (New York, N.Y.)·2025
Same author

Author Correction: Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function.

Nature communications·2025
Same author

Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function.

Nature communications·2025
Same author

Implications for OLE RNA as a natural integral membrane RNA.

RNA (New York, N.Y.)·2025
Same author

Evidence that ribosomal protein bS21 is a component of the OLE ribonucleoprotein complex.

RNA biology·2025
Same author

A Randomized Controlled Trial to Improve the Accuracy of Follow-Up Surveillance Time Intervals in the Electronic Health Record After a Colonoscopy for Colorectal Cancer Screening.

The American journal of gastroenterology·2025

Related Experiment Video

Updated: Feb 8, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Large Noncoding RNAs in Bacteria.

Kimberly A Harris1,2, Ronald R Breaker1,2,3

  • 1Howard Hughes Medical Institute.

Microbiology Spectrum
|July 12, 2018
PubMed
Summary
This summary is machine-generated.

Bacterial large noncoding RNAs (ncRNAs) are crucial for fundamental cellular tasks. While many new ncRNA classes have been discovered, their specific functions remain largely unknown, necessitating further research.

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Related Experiment Videos

Last Updated: Feb 8, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Area of Science:

  • Molecular Biology
  • Genomics

Background:

  • Bacterial noncoding RNAs (ncRNAs) over 200 nucleotides are essential for core cellular functions.
  • Known large bacterial ncRNAs, including rRNA, introns, ribozymes, and riboswitches, exhibit diverse structures and protein-like biochemical activities.

Purpose of the Study:

  • To highlight the discovery of numerous new bacterial large ncRNA classes.
  • To emphasize the need for functional characterization of these newly identified ncRNAs.

Main Methods:

  • Bioinformatics search strategies were employed to identify novel ncRNA classes.
  • Comparative analysis and functional precedent were used to infer potential roles.

Main Results:

  • A significant number of bacterial large ncRNA classes (21) with currently unknown functions have been identified.
  • Preliminary studies offer limited insights into the roles of a few recently discovered classes.

Conclusions:

  • The newly identified bacterial large ncRNAs likely possess complex functions, similar to previously characterized ones.
  • Further research is critical to elucidate the roles of these ncRNAs and advance understanding of fundamental biological processes.