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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Tools for engineering coordinated system behaviour in synthetic microbial consortia.

Nicolas Kylilis1,2, Zoltan A Tuza1,2, Guy-Bart Stan3,4

  • 1Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.

Nature Communications
|July 12, 2018
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Summary

Researchers created new synthetic biology tools for multicellular communication. They developed a library of acyl-homoserine lactone (AHL) devices and software to find non-interfering channels for microbial communities.

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Area of Science:

  • Synthetic Biology
  • Microbial Engineering
  • Systems Biology

Background:

  • Advancing synthetic biology to the multicellular level necessitates robust cell-to-cell communication systems.
  • Quorum-sensing devices, primarily using cognate acyl-homoserine lactone (AHL)/transcription factor pairs, are key for coordinated microbial communities.
  • Limited attention has been given to non-cognate pairs as a design strategy for orthogonal communication.

Purpose of the Study:

  • To develop a comprehensive library of AHL-receiver devices with quantified signal interactions.
  • To create a software tool for automated selection of orthogonal communication channels.
  • To experimentally validate the simultaneous use of multiple communication channels in microbial co-cultures.

Main Methods:

  • Construction and characterization of a large library of AHL-receiver devices.
  • Quantification of signal interactions for both cognate and non-cognate AHL/receiver pairs.
  • Development and application of a computational tool for selecting orthogonal communication channels.
  • Experimental validation of selected orthogonal channels in co-cultured synthetic microbial systems.

Main Results:

  • A large library of AHL-receiver devices was generated, detailing all cognate and non-cognate interactions.
  • A software tool was developed to automatically identify orthogonal communication channels.
  • Up to four orthogonal channels were identified computationally.
  • Three orthogonal channels were successfully demonstrated simultaneously in a co-culture experiment.

Conclusions:

  • The development of a versatile library of AHL-receiver devices and a selection tool enables the design of synthetic consortia with orthogonal communication.
  • This work provides a foundation for engineering complex multicellular synthetic biological systems.
  • The ability to establish multiple non-interfering communication channels facilitates applications in distributed bio-computation, bioprocessing, and cell specialization.