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Researchers developed a novel bioprinting technique to create perfusable in vitro blood vessel models. These biofunctional models mimic natural vessel structure and function, offering potential for drug screening.

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Area of Science:

  • Bioprinting
  • Tissue Engineering
  • Vascular Biology

Background:

  • Existing bioprinted vascular channels often lack natural vessel composition and structural features.
  • Current methods may use less biocompatible hydrogels for easier printing.

Purpose of the Study:

  • To develop a novel bioprinting technique for creating perfusable in vitro blood vessel models.
  • To generate models with biofunctional, multilayer walls mimicking natural blood vessels.

Main Methods:

  • Utilized a drop-on-demand bioprinting technique to construct vessel models.
  • Engineered models with endothelium, smooth muscle cells, and fibroblast matrix.
  • Dynamically cultivated models in bioreactors under physiological flow for three weeks.

Main Results:

  • Achieved high cell viability (>83%) post-printing.
  • Confirmed expression of VE-Cadherin, smooth muscle actin, and collagen IV.
  • Successfully created perfusable vessel models with wall thickness up to 425 µm and diameter ~1 mm.

Conclusions:

  • The novel bioprinting technique effectively produces perfusable vessel models with biofunctional multilayer walls.
  • These models exhibit structural and physiological relevance to natural blood vessels.
  • The developed platform shows potential for creating advanced in vitro disease models for drug pre-screening.