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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Related Experiment Video

Updated: Feb 8, 2026

An Acupoint Catgut-embedding Therapy for Treating Obesity
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Combination Therapies for Obesity.

Michael Camilleri1, Andres Acosta1

  • 1Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic , Rochester, Minnesota.

Metabolic Syndrome and Related Disorders
|July 12, 2018
PubMed
Summary
This summary is machine-generated.

Combination therapies show promise for obesity treatment beyond lifestyle changes. Novel pharmacotherapies and enhanced bariatric procedures offer new hope for effective weight management.

Keywords:
GLP-1glucagonobesitypharmacotherapies

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Bariatric Surgery

Background:

  • Obesity treatment often requires interventions beyond diet and lifestyle modifications.
  • Existing pharmacotherapies and bariatric procedures have limitations.
  • Combination therapies are being explored to improve efficacy.

Purpose of the Study:

  • To review advances in combination therapies for obesity treatment.
  • To examine novel pharmacotherapies and enhanced bariatric procedures.
  • To assess the potential of combination approaches in clinical practice.

Main Methods:

  • Review of experimental combination pharmacotherapies (e.g., pramlintide/phentermine, amylin/bupropion-naltrexone).
  • Analysis of hormonal combinations (e.g., GLP-1 with glucagon, dual incretins, GLP-1/PYY).
  • Evaluation of bariatric procedures (e.g., repeat intragastric balloon, endoscopic intervention, IGB/liraglutide).

Main Results:

  • Experimental pharmacotherapies show potential for obesity management.
  • Hormonal combinations like GLP-1 agonists demonstrate efficacy.
  • Enhanced bariatric interventions, including intragastric balloons with GLP-1 analogs, yield promising results.

Conclusions:

  • Combination therapies represent a promising strategy for obesity treatment.
  • Integrating pharmacotherapies and advanced bariatric procedures may offer improved outcomes.
  • Further clinical introduction of these combination approaches is anticipated.