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Published on: August 3, 2016
Parental occupational pesticide exposure and nonsyndromic orofacial clefts
Jonathan Suhl1, Paul A Romitti1, Carissa Rocheleau2
1a Department of Epidemiology , College of Public Health, The University of Iowa , Iowa City , Iowa.
Abstract:
Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in orofacial cleft development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (1 month before through 3 months after conception) and paternal (3 months before through 3 months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [
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