Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

53.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.7K
Rab Cascades01:25

Rab Cascades

3.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

18.6K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
18.6K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

8.5K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.5K
Cascaded Op Amps01:16

Cascaded Op Amps

1.1K
Operational amplifiers (op-amps) are versatile electronic components that can be interconnected in a cascade - one after another in a linear sequence. This cascading is possible due to their infinite input resistance and zero output resistance, allowing them to maintain their input-output relationships even when connected in series.
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
1.1K
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

2.6K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Balancing misclassification errors in image-based inference using problem domain semantics and a nested cascade architecture.

Neural computing & applications·2025
Same author

Bag-of-words is competitive with sum-of-embeddings language-inspired representations on protein inference.

PloS one·2025
Same author

Medical image classification by incorporating clinical variables and learned features.

Royal Society open science·2025
Same author

Modifying the severity and appearance of psoriasis using deep learning to simulate anticipated improvements during treatment.

Scientific reports·2025
Same author

Few-shot learning for inference in medical imaging with subspace feature representations.

PloS one·2024
Same author

Discrepancy-based diffusion models for lesion detection in brain MRI.

Computers in biology and medicine·2024

Related Experiment Video

Updated: Feb 8, 2026

Deep Learning-Based Segmentation of Cryo-Electron Tomograms
10:25

Deep Learning-Based Segmentation of Cryo-Electron Tomograms

Published on: November 11, 2022

10.9K

Deep Cascade Learning.

Enrique S Marquez, Jonathon S Hare, Mahesan Niranjan

    IEEE Transactions on Neural Networks and Learning Systems
    |July 12, 2018
    PubMed
    Summary

    Deep cascade learning trains deep neural networks efficiently, avoiding vanishing gradients. This novel approach learns better domain-specific features in early layers and offers computational advantages.

    Area of Science:

    • Computer Science
    • Artificial Intelligence
    • Machine Learning

    Background:

    • Deep neural networks (DNNs) training often suffers from the vanishing gradient problem.
    • Standard end-to-end training with backpropagation can hinder effective feature learning in early layers.
    • Cascade correlation, a perceptron training method, inspires alternative approaches.

    Purpose of the Study:

    • To introduce and evaluate a novel bottom-up training algorithm for deep neural networks called deep cascade learning.
    • To demonstrate the algorithm's effectiveness on convolutional neural networks (CNNs) for image classification.
    • To compare deep cascade learning with standard end-to-end training regarding feature representation and efficiency.

    Main Methods:

    • Implemented a layered, bottom-up training approach termed deep cascade learning.

    More Related Videos

    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
    08:20

    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

    Published on: October 27, 2023

    2.6K
    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
    09:34

    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

    Published on: September 25, 2021

    4.5K

    Related Experiment Videos

    Last Updated: Feb 8, 2026

    Deep Learning-Based Segmentation of Cryo-Electron Tomograms
    10:25

    Deep Learning-Based Segmentation of Cryo-Electron Tomograms

    Published on: November 11, 2022

    10.9K
    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
    08:20

    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

    Published on: October 27, 2023

    2.6K
    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
    09:34

    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

    Published on: September 25, 2021

    4.5K
  • Applied the algorithm to convolutional layers within neural network architectures.
  • Conducted empirical evaluations on CIFAR-10 and CIFAR-100 datasets, comparing against end-to-end backpropagation.
  • Main Results:

    • Deep cascade learning circumvents the vanishing gradient problem by training layers sequentially.
    • The approach learns superior, domain-specific feature representations in early network layers compared to end-to-end training.
    • Recognition accuracy improved progressively with added layers, showing discriminative features learned at each stage.

    Conclusions:

    • Deep cascade learning offers a viable alternative to end-to-end training for deep neural networks.
    • The method provides significant computational and memory advantages.
    • Deep cascade learning can serve as an effective pretraining algorithm for enhanced performance.