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Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Mass and weight are often used interchangeably in everyday conversation. For example,  medical records often show our weight in kilograms, but never in the correct units of newtons. In physics, however, there is an important distinction. Weight is the pull of the Earth on an object. It depends on the distance from the center of the Earth. Weight dramatically varies if we leave the Earth's surface, unlike mass, which does not vary with location. On the Moon, for example, the...
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The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Beyond Sharing Weights for Deep Domain Adaptation.

Artem Rozantsev, Mathieu Salzmann, Pascal Fua

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    |July 12, 2018
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    Summary
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    Domain Adaptation techniques improve classifier performance across different data domains. A novel two-stream architecture, relating but not sharing weights, outperforms shared-weight models for object recognition.

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    Area of Science:

    • Computer Science
    • Machine Learning
    • Artificial Intelligence

    Background:

    • Classifier performance degrades when applied to new data domains.
    • Domain Adaptation addresses this by leveraging source domain data for target domains.
    • Current methods often use shared weights for domain-invariant features.

    Purpose of the Study:

    • To investigate an alternative to shared-weight deep architectures for Domain Adaptation.
    • To propose a novel two-stream architecture that explicitly models domain shifts.
    • To improve classifier accuracy in target domains with limited or no annotated data.

    Main Methods:

    • Introduced a two-stream neural network architecture.
    • One stream processes source domain data, the other processes target domain data.
    • Weights in corresponding layers are related but not shared, allowing explicit modeling of domain shift.

    Main Results:

    • The proposed two-stream architecture achieved higher accuracy than state-of-the-art methods.
    • Outperformed shared-weight networks on object recognition and detection tasks.
    • Demonstrated consistent improvements in both supervised and unsupervised Domain Adaptation settings.

    Conclusions:

    • Explicitly modeling domain shifts via related, non-shared weights is more effective than shared weights.
    • The proposed two-stream approach offers a superior solution for Domain Adaptation.
    • This method enhances classifier robustness and accuracy across diverse data domains.