Automatic Retinal Layer Segmentation of OCT Images With Central Serous Retinopathy

In this paper, an automatic method is reported for simultaneously segmenting layers and fluid in 3-D OCT retinal images of subjects suffering from central serous retinopathy. To enhance contrast between adjacent layers, multiscale bright and dark layer detection filters are proposed. Due to appearance of serous fluid or pigment epithelial detachment caused fluid, contrast between adjacent layers is often reduced, and also large morphological changes are caused. In addition, 24 features are designed for random forest classifiers. Then, 8 coarse surfaces are obtained based on the trained random forest classifiers. Finally, a hypergraph is constructed based on the smoothed image and the layer structure detection responses. A modified live wire algorithm is proposed to accurately detect surfaces between retinal layers, even though OCT images with fluids are of low contrast and layers are largely deformed. The proposed method was evaluated on 48 spectral domain OCT images with central serous retinopathy. The experimental results showed that the proposed method outperformed the state-of-art methods with regard to layers and fluid segmentation.